THEPSYCHEDELICLIBRARY

Research · Clinical Trials · Evidence

The research,
made readable.

Plain-language summaries of the published studies and clinical trials on psychedelic and ketamine therapy, with an honest read on how strong the evidence really is.

Start with the researchBrowse clinical trials

Research

Guides and study library

Start-here chapters on how these treatments work, plus a searchable library of study summaries.

Clinical Trials

Trials tracker

Active and completed trials around the world, with a filter for trials running in Canada.

Conditions

Evidence by condition

Depression, PTSD, chronic pain and more: what the research shows so far, and how confident we can be.

Start here

  1. 01What ketamine therapy isHow ketamine is used as a treatment, the different ways it's given, and how that differs from recreational use.
  2. 02How psychedelics and ketamine work in the brainWhat researchers think is happening, from receptors to brain networks, and what's still unknown.
  3. 03What the evidence saysAn honest overview of where the research is strong, where it's promising and where it's thin.
  4. 04Safety, side effects and who shouldn't take partKnown risks, common side effects and the medical and psychiatric screening used in clinical research.
  5. 05What a treatment actually involvesScreening, preparation, dosing sessions and integration, as described in clinical research protocols.
  6. 06Cost and coverage in CanadaWhat shapes the cost of treatment, and what public and private plans may cover.
  7. 07Legal status and access in CanadaHow ketamine, psilocybin, MDMA and other psychedelics are regulated, and the legal routes to access that exist today.
  8. 08History and common mythsWhere psychedelic medicine came from, why research stopped and restarted, and the myths that still circulate.

Latest studies

RCT

DMT plus harmine changes the pattern of brain activity states on EEG in healthy adults

Journal of psychopharmacology (Oxford, England), 2026

Open-label trial

Psilocybin therapy for bipolar II depression: a small open-label dose-escalation trial

The Journal of clinical psychiatry, 2026

Other

Review: psychedelic treatments in psychiatry still count as experimental

Orvosi hetilap, 2026

Survey

Survey compares the sense of familiarity in psychedelic experiences with déjà vu and memory

Journal of psychoactive drugs, 2026

Systematic review

Systematic review of psilocybin for depression: how it may work and how well it works

International journal of molecular sciences, 2026

Observational

What people say about 5-MeO-DMT: a thematic analysis of 120 Reddit posts

Journal of psychoactive drugs, 2026

Evidence by condition

Depression and treatment-resistant depression

What research shows on ketamine, esketamine, psilocybin, DMT and 5-MeO-DMT for depression, including depression that hasn't responded to treatment.

PTSD

What the research shows about MDMA-assisted therapy, ketamine and other psychedelic treatments for post-traumatic stress disorder.

Chronic pain

What the research shows about ketamine infusions and emerging psychedelic research for chronic and neuropathic pain.

Alcohol and substance use

What the research shows about psilocybin, ketamine, LSD, 5-MeO-DMT and ibogaine for alcohol use disorder and other addictions.

Anxiety and end-of-life distress

What the research shows about psilocybin and LSD for anxiety, including anxiety and depression in people facing serious illness.

Suicidal thoughts

What the research shows about ketamine and esketamine for rapid reduction of suicidal thoughts, and what isn't known.